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Mycobacterium senuense sp. nov., a slowly growing, non-chromogenic species closely related to the Mycobacterium terrae complex

¹ Department of Microbiology and Immunology, Cancer Research Institute and Liver Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea
² Korean Institute of Tuberculosis, Korean National Tuberculosis Association, Seoul 137-140, Republic of Korea

Correspondence
Bum-Joon Kim
kbumjoon{at}snu.ac.kr

A previously undescribed, slowly growing, non-chromogenic mycobacterium, isolated from a Korean patient with a symptomatic pulmonary infection, is described as representing a novel species. Its 16S rRNA gene sequence was unique and phylogenetic analysis based on 16S rRNA gene sequences showed that this organism belonged to the Mycobacterium terrae subclade. Phenotypically, the strain was generally similar to M. terrae and Mycobacterium nonchromogenicum, but its growth rate was slower than those of other M. terrae complex strains. A unique mycolic acid profile and phylogenetic analysis based on two different alternative chronometer molecules, hsp65 and rpoB, confirm the taxonomic status of this strain as a representative of a novel species. The name Mycobacterium senuense sp. nov. is proposed, with the type strain 05-832^T (=DSM 44999^T =KCTC 19147^T).

The GenBank/EMBL/DDBJ accession numbers for the partial rpoB, 16S rRNA gene and hsp65 sequences of strain 05-832^T are DQ536407–DQ536409, respectively.

A detailed antibiotic susceptibility profile of strain 05-832^T, a comparison of the mycolic acid TLC profiles of strain 05-832^T and M. nonchromogenicum ATCC 19530^T and alignments and neighbour-joining trees based on partial hsp65 and rpoB sequences are available as supplementary material with the online version of this paper.