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International Journal of Systematic and Evolutionary Microbiology, Vol 51, 797-814, Copyright © 2001 by Society for General Microbiology
AS Anderson and EMH Wellington
Natural Products Drug Discovery Microbiology, Merck Research Laboratories, PO Box 2000, RY80Y-300, Rahway, NJ 07065, USA
The streptomycetes, producers of more than half of the 10000 documented bioactive compounds, have offered over 50 years of interest to industry and academia. Despite this, their taxonomy remains somewhat confused and the definition of species is unresolved due to the variety of morphological, cultural, physiological and biochemical characteristics that are observed at both the inter- and the intraspecies level. This review addresses the current status of streptomycete taxonomy, highlighting the value of a polyphasic approach that utilizes genotypic and phenotypic traits for the delimitation of species within the genus.
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