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Amycolatopsis alba sp. nov., Isolated from Soil

The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285

^* Corresponding author.

ABSTRACT

A new Amycolatopsis species isolated from soil produces a new glycopeptide antibiotic related to vancomycin. Traditional taxonomic methods and contemporary fatty acid analysis techniques were used to establish the position of this species. The hyphae fragment extensively when the organism is cultured in liquid media. The organism is characterized by white aerial hyphae that bear long chains of cylindrical conidia. The reverse side is yellowish brown; a faint light brown soluble pigment is occasionally produced. The organism has a type IV cell wall (meso-diaminopimelic acid), a type A whole-cell sugar pattern, and a type PII phospholipid pattern. Mycolic acids are not present in whole-cell hydrolysates. The major menaquinone is MK-9(H₄); there is also a minor amount of MK-8(H₄). The name proposed for this new species is Amycolatopsis alba. The type strain is strain A83850 (= NRRL 18532).

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